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Wen Hsiung Li

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Citizenship
  
Taiwanese-American

Doctoral advisor
  
Wendell Fleming

Name
  
Wen-Hsiung Li

Nationality
  
Taiwanese


Wen-Hsiung Li wwwbalzanorguploadfacvfq55vracrjmjhrgnubqs2010

Born
  
Wen Hsiung Li September 22, 1942 (age 81) Pingtung, Taiwan (
1942-09-22
)

Institutions
  
University of Chicago Academia Sinica University of Texas University of Wisconsin-Madison

Alma mater
  
Brown University, Providence, RI, USA National Central University, Taiwan Chung-Yuang College of Science and Engineering, Taiwan

Thesis
  
Mathematical Studies On Mutational Damages In Finite Populations (1972)

Education
  
National Taiwan University

Books
  
Molecular Evolution PB

Fields
  
Mathematics, Genetics, Evolutionary biology, Genomics

Other academic advisors
  
Masatoshi Nei

Big Data and Science | Wen Hsiung Li


Wen-Hsiung Li (Traditional Chinese:李文雄, 1942-) is a Taiwanese American scientist working in the fields of molecular evolution, population genetics, and genomics. He is currently the James Watson Professor of Ecology and Evolution at the University of Chicago and a Principal Investigator at the Institute of Information Science and Genomics Research Center, Academia Sinica, Taiwan.

Contents

Wen-Hsiung Li wwwbalzanorguploadLiWenHsungPremioBalzan200

Biography

Li was born in 1942 in Taiwan. In 1968 he received a M.S. in geophysics from National Central University. In 1972 he received his Ph.D in applied mathematics at Brown University in Providence, Rhode Island. From 1972 to 1973 he was a post-doctoral researcher at the University of Wisconsin Madison (genetics), working with James F. Crow. In 1973 he moved to the University of Texas, where he was appointed as a professor in 1984. Since 1998 he has been a professor at The University of Chicago.

Scientific contributions

Professor Li is best known for his studies on the molecular clock (i.e. rates and patterns of DNA sequence evolution) and on the patterns and consequences of gene duplication.

In 2003, he received the international Balzan Prize for his contribution to genetics and evolutionary biology, and was elected to the National Academy of Sciences, who cited his role in "establishing theoretical foundations for molecular phylogenetics and evolutionary genomics"[1]. He is the author of the first texts in the field of molecular evolution, Molecular Evolution and Fundamentals of Molecular Evolution (co-authored with Dan Graur), and an author on more than 200 peer-reviewed publications.

Honors

  • Academia Sinica Taiwan, 1998
  • American Academy of Arts and Sciences, 1999
  • President of the “Society for Molecular Biology and Evolution”, 2000
  • National Academy of Sciences, 2003
  • Balzan prize 2003 for genetics and evolution (The third recipient, following Sewall Wright (1984) and John Maynard Smith (1991)).
  • Inaugural HUGO/ "Chen Award" for Achievement in Human Genetic and Genomic Research, 2008
  • Selected publications

  • Chu, T. -C.; Lu, C. -H.; Liu, T.; Lee, G. C.; Li, W. -H.; Shih, A. C. -C. (2013). "Assembler for de novo assembly of large genomes". Proceedings of the National Academy of Sciences. 110 (36): E3417. doi:10.1073/pnas.1314090110. 
  • Gu, Z.; Steinmetz, L. M.; Gu, X.; Scharfe, C.; Davis, R. W.; Li, W. H. (2003). "Role of duplicate genes in genetic robustness against null mutations". Nature. 421 (6918): 63–6. PMID 12511954. doi:10.1038/nature01198. 
  • Makova, K. D.; Li, W. H. (2002). "Strong male-driven evolution of DNA sequences in humans and apes". Nature. 416 (6881): 624–6. PMID 11948348. doi:10.1038/416624a. 
  • Li, W. H.; Gu, Z.; Wang, H.; Nekrutenko, A. (2001). "Evolutionary analyses of the human genome". Nature. 409 (6822): 847–9. PMID 11237007. doi:10.1038/35057039. 
  • Tan, Y.; Li, W. H. (1999). "Vision: Trichromatic vision in prosimians". Nature. 402 (6757): 36. PMID 10573416. doi:10.1038/46947. 
  • Shyue, S.; Hewett-Emmett, D.; Sperling, H.; Hunt, D.; Bowmaker, J.; Mollon, J.; Li, W.H. (1995). "Adaptive evolution of color vision genes in higher primates". Science. 269 (5228): 1265–7. PMID 7652574. doi:10.1126/science.7652574. 
  • Shimmin, L. C.; Chang, B. H. J.; Li, W. H. (1993). "Male-driven evolution of DNA sequences". Nature. 362 (6422): 745–7. PMID 8469284. doi:10.1038/362745a0. 
  • Graur, D.; Hide, W. A.; Li, W. H. (1991). "Is the guinea-pig a rodent?". Nature. 351 (6328): 649–52. PMID 2052090. doi:10.1038/351649a0. 
  • Graur, D. A. N.; Li, W.H. (1991). "Neutral mutation hypothesis test". Nature. 354 (6349): 114. doi:10.1038/354114e0. 
  • Wolfe, K. H.; Sharp, P. M.; Li, W. H. (1989). "Mutation rates differ among regions of the mammalian genome". Nature. 337 (6204): 283–5. PMID 2911369. doi:10.1038/337283a0. 
  • Gouy, M.; Li, W. H. (1989). "Phylogenetic analysis based on rRNA sequences supports the archaebacterial rather than the eocyte tree". Nature. 339 (6220): 145–7. PMID 2497353. doi:10.1038/339145a0. 
  • Sharp, P.; Shields, D.; Wolfe, K.; Li, W.H. (1989). "Chromosomal location and evolutionary rate variation in enterobacterial genes". Science. 246 (4931): 808–10. PMID 2683084. doi:10.1126/science.2683084. 
  • Sharp, P. M.; Li, W.H. (1988). "Understanding the origins of AIDS viruses". Nature. 336 (6197): 315. PMID 3194016. doi:10.1038/336315a0. 
  • Li, W. H.; Tanimura, M. (1987). "The molecular clock runs more slowly in man than in apes and monkeys". Nature. 326 (6108): 93–6. PMID 3102974. doi:10.1038/326093a0. 
  • Li, W. H.; Gojobori, T.; Nei, M. (1981). "Pseudogenes as a paradigm of neutral evolution". Nature. 292 (5820): 237–9. PMID 7254315. doi:10.1038/292237a0. 
  • Nei, M.; Li, W. H. (1979). "Mathematical model for studying genetic variation in terms of restriction endonucleases". Proceedings of the National Academy of Sciences. 76 (10): 5269–73. PMC 413122 . PMID 291943. doi:10.1073/pnas.76.10.5269. 
  • Selected books

  • Li, W.-H. (2006). Molecular Evolution. Sinauer. ISBN 0-87893-480-4. 
  • Dan Graur; Wen-Hsiung Li (2000). Fundamentals of Molecular Evolution: Second Edition. Sinauer Associates, Inc. 
  • References

    Wen-Hsiung Li Wikipedia