Wake is a surname. Notable people with the surname include:
Brian Wake (born 1982), English footballer
Cameron Wake (born 1982), American football linebacker
David B. Wake (born 1936), biologist and herpetologist
Harry Wake (1901–1981), English footballer
Hereward the Wake (born 1035), 11th-century Anglo-Saxon leader
Isaac Wake (1580–1632), English diplomat and political commentator
John Wake (born 1953), English cricketer
Margaret Wake, 3rd Baroness Wake of Liddell (1297–1349), wife of Edmund of Woodstock, 1st Earl of Kent
Marvalee Wake (born 1939), American biologist
Nancy Wake (1912–2011), New Zealand born Australian who served as a British spy during World War II
Neil Vincent Wake (born 1948), United States federal judge
Ric Wake, record producer
Robert A. Wake, 1966 champion of the Scripps National Spelling Bee
Thomas Wake, 2nd Baron Wake of Liddell (1297–1349), English baron
William Wake (1657–1737), Archbishop of Canterbury
William Wake (cricketer) (1852–1896), English amateur first-class cricketer
William Wake (governor), governor of Bombay
