Wain is a surname. Notable people with the surname include:
Bea Wain (born 1917), American Big Band-era singerDavid Wain (born 1969), American comedian, writer, actor and directorEdward Wain, aka Robert Towne (born 1934), American screenwriter and directorJohn Wain (1925–1994), English poet, novelist, and critic, associated with the literary group "The Movement"Louis Wain (1860–1939), English artist known for his drawings featuring anthropomorphised large-eyed cats and kittensRichard William Leslie Wain (1896–1917), Welsh recipient of the Victoria CrossWilliam Wain Prior (1876–1946), Commander-in-Chief of the Royal Danish Army, 1939–1941