Species Human Entrez 80326 | Human Mouse Ensembl ENSG00000135925 | |
Aliases WNT10A, OODD, SSPS, STHAG4, Wnt family member 10A External IDs MGI: 108071 HomoloGene: 22525 GeneCards: WNT10A | ||
Wnt-10a is a protein that in humans is encoded by the WNT10A gene.
Contents
Function
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family.
Clinical significance
WNT10A is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.
Mutations in the WNT10A gene are associated with Schöpf–Schulz–Passarge syndrome and hypodontia.