Rahul Sharma (Editor)

WASF1

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Species
  
Entrez
  
8936

Human
  
Ensembl
  
ENSG00000112290

WASF1

Aliases
  
WASF1, SCAR1, WAVE, WAVE1, WAS protein family member 1

External IDs
  
MGI: 1890563 HomoloGene: 2920 GeneCards: WASF1

Wiskott-Aldrich syndrome protein family member 1, also known as WASP-family verprolin homologous protein 1 (WAVE1), is a protein that in humans is encoded by the WASF1 gene.

Contents

Function

The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP) family, plays a critical role downstream of Rac, a Rho-family small GTPase, through its involvement in the WAVE regulatory complex in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro.

Clinical significance

Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton.

Interactions

WASF1 has been shown to interact with BAIAP2 and Profilin 1.

References

WASF1 Wikipedia


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