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Vitamin B12 transporting ATPase

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EC number
  
3.6.3.33

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

MetaCyc
  
metabolic pathway

In enzymology, a vitamin B12-transporting ATPase (EC 3.6.3.33) is an enzyme that catalyzes the chemical reaction

ATP + H2O + vitamin B12out ⇌ ADP + phosphate + vitamin B12in

The 3 substrates of this enzyme are ATP, H2O, and vitamin B12, whereas its 3 products are ADP, phosphate, and vitamin B12.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (vitamin B12-importing). This enzyme participates in abc transporters - general.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1L7V and 2QI9.

References

Vitamin B12-transporting ATPase Wikipedia
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