Symbol Vesiculo_matrix InterPro IPR009397 SUPERFAMILY 1lg7 | Pfam PF06326 SCOP 1lg7 OPM superfamily 446 | |
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The family of vesiculovirus matrix proteins consists of several matrix proteins of the vesicular stomatitis virus, also known as VSIV or VSV. The matrix (M) protein of the virus causes many of the cytopathic effects of VSV, including an inhibition of host gene expression and the induction of cell rounding. It has been shown that M protein also induces apoptosis in the absence of other viral components. It is thought that the activation of apoptotic pathways causes the inhibition of host gene expression and cell rounding by M protein.
Contents
Function
These proteins play a major role in assembly and budding of VSIV virions. Their main role is to aid virus assembly. They starts by shutting off host cell transcription by inhibiting mRNA nuclear export through direct interaction with the host RAE1-NUP98 complex. This inhibits interferon signaling and thus establishment of antiviral state in virus infected cells. In turn, this induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell. Enveloped viruses acquire their membrane by budding at a membrane of their host cell.
Structure
The structure of these matrix proteins has revealed a single-globular domain with a new fold. The N-terminal part consists of a large five-stranded anti-paralle beta-sheet packed against two alpha-helices; the C-terminal part comprises a small two stranded anti-parallel beta-sheet and an alpha-helix.