Puneet Varma (Editor)

Vesicular transport protein

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A vesicular transport protein, or vesicular transporter, is a membrane protein that regulates or facilitates the movement of specific molecules (transporter substrates) across a vesicular membrane. As a result, vesicular transporters govern the concentration of molecules within a vesicle.

Contents

Types

Examples include:

  • Archain
  • ARFs
  • Clathrin
  • Caveolin
  • Dynamin and related proteins, such as the EHD protein family
  • Rab proteins
  • SNAREs
  • Sorting nexins
  • Synaptotagmin
  • TRAPP complex
  • Pathways

    There are multiple pathways, each using its own coat and GTPase.

  • COP 1 (Cytosolic coat protein complex ) : retrograde transport ; Golgi ----> Endoplasmic reticulum
  • COP 2 (Cytosolic coat protein complex ) : anterograde transport ; RER -----> cis-Golgi
  • Clathrin : trans-Golgi ----> Lysosomes, Plasma membrane ----> Endosomes (receptor-mediated endocytosis)
  • References

    Vesicular transport protein Wikipedia