Formula C36H51NO11 | Molar mass 673.79 g/mol | |
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10micromolar veratridine 24hpf avi
Veratridine is a steroid-derived alkaloid from plants in the Liliaceae family that functions as a neurotoxin by abolishing inactivation of sodium ion channels. It is primarily obtained from the herb Veratrum and sabadilla seeds. It binds to intramembrane receptor site 2 and increases intracellular Ca2+ concentration. It acts by preferentially binding to activated Na+ channels causing persistent activation that leads to increased nerve excitability.
Contents
Medical vocabulary what does veratridine mean
Isolation
Isolated from seeds of Schoenocaulon officinale, and from rhizomes of Veratrum album.
Chemistry
Veratridine is a derivative, the 3-veratroate ester, of veracevine, which belongs to the class of C-nor-D-homosteroidal alkaloids. The molecular structure and stereochemistry of this and related alkaloids were only established after decades of chemical investigations. The structure of veratridine has been confirmed by NMR spectroscopy and X-ray crystallography.
Obsolete use
It is used in ointments for the treatment of neuralgia and rheumatoid pain.