Van Hoof is a Dutch toponymic surname. Notable people with the surname include:
Harry van Hoof (born 1943), Dutch composer, conductor and music arranger
Henk van Hoof (born 1947), Dutch politician
Jan van Hoof (1922–1944), Dutch Resistance member
Jef van Hoof (1886–1959), Belgian composer and conductor
Jeremy Van Hoof (born 1981), Canadian ice hockey player
Mary Ann Van Hoof (1909–1984), American Marian visionary