Valine dehydrogenase (NADP )

In enzymology, a valine dehydrogenase (NADP⁺) (EC 1.4.1.8) is an enzyme that catalyzes the chemical reaction

L-valine + H₂O + NADP⁺ ⇌ 3-methyl-2-oxobutanoate + NH₃ + NADPH + H⁺

The 3 substrates of this enzyme are L-valine, H₂O, and NADP⁺, whereas its 4 products are 3-methyl-2-oxobutanoate, NH₃, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-valine:NADP⁺ oxidoreductase (deaminating). Other names in common use include valine dehydrogenase (nicotinanide adenine dinucleotide phosphate), and valine dehydrogenase (NADP⁺).