Species Human Entrez 51652 | Human Mouse Ensembl ENSG00000115561 | |
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Aliases CHMP3, NEDF, VPS24, CGI-149, charged multivesicular body protein 3 External IDs MGI: 1913950 HomoloGene: 6368 GeneCards: CHMP3 | ||
Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.
Contents
Function
This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.
Interactions
VPS24 has been shown to interact with IGFBP7.
References
VPS24 Wikipedia(Text) CC BY-SA