Girish Mahajan (Editor)

VPS24

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Species
  
Entrez
  
51652

Human
  
Ensembl
  
ENSG00000115561

VPS24

Aliases
  
CHMP3, NEDF, VPS24, CGI-149, charged multivesicular body protein 3

External IDs
  
MGI: 1913950 HomoloGene: 6368 GeneCards: CHMP3

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.

Contents

Function

This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.

Interactions

VPS24 has been shown to interact with IGFBP7.

References

VPS24 Wikipedia


Similar Topics