Species Human Entrez 2321 | Human Mouse Ensembl ENSG00000102755 | |
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Aliases FLT1, FLT, FLT-1, VEGFR-1, VEGFR1, fms related tyrosine kinase 1 External IDs MGI: 95558 HomoloGene: 134179 GeneCards: FLT1 | ||
Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.
Contents
Function
Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM]
Interactions
FLT1 has been shown to interact with PLCG1 and vascular endothelial growth factor B (VEGF-B).
References
VEGFR1 Wikipedia(Text) CC BY-SA