Supriya Ghosh (Editor)

VAMP2

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Species
  
Entrez
  
6844

Human
  
Ensembl
  
ENSG00000220205

VAMP2

Aliases
  
VAMP2, SYB2, VAMP-2, vesicle associated membrane protein 2

External IDs
  
MGI: 1313277 HomoloGene: 7591 GeneCards: VAMP2

Vesicle-associated membrane protein 2 is a protein that in humans is encoded by the VAMP2 gene.

Contents

Function

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. VAMP2 is thought to participate in neurotransmitter release at a step between docking and fusion. Mice lacking functional synaptobrevin2/VAMP2 gene cannot survive after birth, and have a dramatically reduced synaptic transmission, around 10% of control. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and complexin. It also forms a distinct complex with synaptophysin.

Clinical significance

VAMP2 is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.

Interactions

VAMP2 has been shown to interact with:

References

VAMP2 Wikipedia


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