Species Human Entrez 7307 | Human Mouse Ensembl ENSG00000160201 | |
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Aliases U2AF1, FP793, RN, RNU2AF35, U2AFBP, U2 small nuclear RNA auxiliary factor 1 External IDs HomoloGene: 134334 GeneCards: U2AF1 | ||
Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.
Contents
Function
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.
Interactions
U2 small nuclear RNA auxiliary factor 1 has been shown to interact with:
References
U2 small nuclear RNA auxiliary factor 1 Wikipedia(Text) CC BY-SA