Twenty Love Poems and a Song of Despair

Twenty Love Poems and a Song of Despair (Spanish: Veinte poemas de amor y una canción desesperada) is a collection of romantic poems by the Chilean poet Pablo Neruda, first published in 1924 by Editorial Nascimento of Santiago, when Neruda was 19. It was Neruda's second published work, after Crepusculario (Editorial Nascimento, 1923) and made his name as a poet.

Veinte poemas was controversial for its eroticism, especially considering its author's very young age. Over the decades, Veinte poemas has become Neruda's best-known work, and has sold more than 20 million copies. The book has been translated into many languages; in English, the translation was made by poet W. S. Merwin.

It remains the best selling poetry book in the Spanish language ever, almost 100 years after its first publication.

In 2001, the alternative rock musician Lynda Thomas released as a single the flamenco song Ay, Ay, Ay, which was based on this work.