Tweedie is a surname of Scottish origin. The name is a habitational name from Tweedie, located in the parish of Stonehouse, south of Glasgow. The origin and meaning of the name is unknown. Notable people with the surname include:
Alexander Tweedie (1794–1884), Scottish physician and writerAndrew Tweedie (born 1975), South African cricketerDave Tweedie (born 1968), American composer, multi-instrumentalist and record producerDavid Tweedie (born 1944), Scottish accountantEthel Brilliana Tweedie (1862–1940), British author and feministFrederick Tweedie (1877–after 1925), Canadian politicianGeorge R. Tweedie (1857–after 1893), English businessmanHerbert J. Tweedie (1864–1906), English golf course architectHugh Tweedie, English officer in the Royal NavyIrina Tweedie (1907–1999), Russian-British SufiJill Tweedie (1936–1993), British feminist, writer and broadcasterLemuel John Tweedie (1849–1917), Canadian politician and father of Frederick TweedieMaurice Tweedie, British medical physicist and statisticianMichael Tweedie (1907–1993), naturalist and archaeologistRob Tweedie (born 1979), American musicianScott Tweedie (born 1988), Australian television and radio presenterStephen Tweedie (born 1969), Scottish software developerThomas Tweedie (1871–1944), Canadian politician and Chief JusticeWilliam Menzies Tweedie (1826–1878), Scottish portrait painter