Density 876 kg/m³ Appearance clear liquid, colorless | Melting point -95 °C | |
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Trimethylsilyl azide ((CH3)3SiN3) is a chemical compound used as a reagent in organic chemistry.
Contents
Preparation
Trimethylsilyl azide is commercially available. It may be prepared by the reaction of trimethylsilyl chloride and sodium azide:
TMSCl + NaN3 → TMSN3 + NaCl (TMS = (CH3)3Si)Applications
It is considered a safer replacement for hydrazoic acid in many reactions. It will however over time hydrolyze to hydrazoic acid and therefore it must be stored free of moisture It has been used in the Oseltamivir total synthesis.
Safety
Trimethylsilyl azide is incompatible with moisture, strong oxidizing agents, and strong acids.
References
Trimethylsilyl azide Wikipedia(Text) CC BY-SA