Transmembrane Protein 175

Transmembrane Protein 175

Transmembrane Protein 175, or TMEM175, is a transmembrane protein that is not yet well understood by the scientific community. It is predicted to have many orthologs across eukaryotes.

Contents

• Transmembrane Protein 175
• General Properties
• Secondary Structure
• Function
• Expression
• Homology
• Predicted Post Translational Modification
• References

General Properties

Secondary Structure

The secondary structure of TMEM175 is predicted to consist of alternating pairs of alpha helices and beta sheets.

Function

The function of TMEM175 is not yet fully understood. It contains two regions of a domain of unknown function 1211(DUF1211). This domain of unknown function has been found in eukaryotes, bacteria, and archaea

Expression

Based on human and mouse EST profiles and a human tissue GEO profile, TMEM175 appears to be expressed at a relatively high level(75-98%) in normal tissues. TMEM175 appears to be down regulated in stage three ovarian cancer

Homology

Transmembrane protein 175 has no paralogs. It does have orthologs within eukaryotes. The following table presents some of the orthologs found using searches in BLASTand BLAT. This list does not contain all of the orthologs for TMEM175. It is meant to display the diversity of species for which orthologs are found.

Predicted Post-Translational Modification

Using various tools at ExPASy the following are possible post-translational modifications for TMEM175.

The N-myristoylation sites are conserved in vertebrates.