Trans resveratrol di O methyltransferase

Trans-resveratrol di-O-methyltransferase (EC 2.1.1.240, ROMT, resveratrol O-methyltransferase, pterostilbene synthase) is an enzyme with systematic name S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase. This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + trans-resveratrol ⇌ 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction)(1a) S-adenosyl-L-methionine + trans-resveratrol ⇌ S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene ⇌ S-adenosyl-L-homocysteine + pterostilbene

The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.