Tooke is a surname, and may refer to
Andrew Tooke (1673–1732), English scholar, headmaster, and translator of Tooke's Pantheon
Charles Emery Tooke, Jr. (1912–1986), U.S. attorney and politician from Louisiana
John Horne Tooke (1736–1812), English clergyman, politician, and philologist
John Tooke (born 1949), English professor of medicine and medical reform advocate
Thomas Tooke (1774–1858), English economist and economic statistician, son of William Tooke (1744–1820), brother of William Tooke (1777–1863)
William Tooke (1744–1820), British clergyman and historian of Russia, father of William Tooke (1777–1863) and Thomas Tooke
William Tooke (1777–1863), British lawyer, son of William Tooke (1744–1820), brother of Thomas Tooke
William Tooke (MP) for Horsham (UK Parliament constituency)
Gerald Tooke (born 1954), Crystals machinist
