ATC code none Metabolism Excretion Urine Molar mass 440.6 g/mol ChEMBL ID 35057 IUPHAR/BP 101 | Legal status Development terminated Biological half-life 1.4 hours CAS Number 87691-91-6 Pubchem 55752 ChemSpider ID 50348 | |
 | ||
What does tiospirone mean
Tiospirone (BMY-13,859), also sometimes called tiaspirone or tiosperone, is an atypical antipsychotic of the azapirone class. It was investigated as a treatment for schizophrenia in the late 1980s and was found to have an effectiveness equivalent to those of typical antipsychotics in clinical trials but without causing extrapyramidal side effects. However, development was halted and it was not marketed. Perospirone, another azapirone derivative with antipsychotic properties, was synthesized and assayed several years after tiospirone. It was found to be both more potent and more selective in comparison and was commercialized instead.
Contents
Tiospirone acts as a 5-HT1A receptor partial agonist, 5-HT2A, 5-HT2C, and 5-HT7 receptor inverse agonist, and D2, D4, and α1-adrenergic receptor antagonist.
Binding profile