Neha Patil (Editor)

Tideglusib

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PubChem CID
  
11313622

3D model (Jmol)
  
Interactive image

Pubchem
  
11313622

Formula
  
C19H14N2O2S

Molar mass
  
334.392 g/mol

ChemSpider ID
  
9488589

Tideglusib fileselleckchemcomdownloadsstructTideglusibc

Tideglusib (NP-12, NP031112) is a potent, selective and irreversible small molecule non-ATP-competitive GSK-3 inhibitor.

Contents

How to pronounce tideglusib


Potential applications

Tideglusib is under investigation for multiple applications:

  • Alzheimer's disease and Progressive supranuclear palsy. As of 2017 it was undergoing Phase IIa and IIb clinical trials. The first trial to be published (in English) was Phase II and demonstrated that tideglusib was well tolerated, except for some moderate, asymptomatic, fully reversible increases in liver enzymes (≥2.5xULN; where ULN=Upper Limit of Normal).
  • Tooth repair mechanisms that promotes dentine reinforcement of a sponge structure until the sponge biodegrades, leaving a solid dentine structure. In 2016 it was successfully trialled for permanently filling 0.14mm holes in mouse teeth.
  • Autism spectrum disorders in adolescents.

    • References

    Tideglusib Wikipedia
    (Text) CC BY-SA