Species Human Entrez 7072 | Human Mouse Ensembl ENSG00000116001 | |
Aliases TIA1, TIA-1, WDM, TIA1 cytotoxic granule-associated RNA binding protein External IDs MGI: 107914 HomoloGene: 20692 GeneCards: TIA1 | ||
Gene music using protein sequence of tia1 tia1 cytotoxic granule associated rna binding protein
TIA1 cytotoxic granule-associated RNA binding protein is a protein that in humans is encoded by the TIA1 gene.
Contents
- Gene music using protein sequence of tia1 tia1 cytotoxic granule associated rna binding protein
- Function
- References
Function
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
References
Tia1 cytotoxic granule-associated rna binding protein Wikipedia(Text) CC BY-SA