The Thieme and Wagner Brewing Company was started by Frederick August Thieme and John Wagner in 1860. The brewery was located in Lafayette, Indiana at the corner of 4th and Union Streets. At its height the brewery was producing 100,000 barrels of beer annually and was the 6th largest in Indiana. The brewery lasted until 1918, when Prohibition forced it to become The National Fruit Juice Company, which produced near beer in addition to an apple drink called Apella. A rise in the price of ingredients and the Great Depression caused the company to close in 1930.
With the repeal of Prohibition Lafayette Brewing Inc. moved into the old Thieme & Wagner brewery and produced their own take on T & W's famous Ye Tavern Brew. Lafayette Brewery Inc. closed down around 1940.
The Thieme and Wagner Brewing Company is owned by fifth generation Thiemes John and Brian.