Introduction: Wile E. Coyote, apparently famished, wads up a bunch of mud to make a lookalike chicken. He shovels it in an adobe oven, then one he is done roasting it he sits down to "eat" it, with less than perfect results (a tooth falls off his mouth in the process). So he makes a second fixture - a trash can - and throws the "chicken" in it, proving he is indeed Famishius Fantasticus. An object bowls everything over and the "chicken" in the "trash can" lands on him. A question mark appears . Wile E. looks out to see what has everything bowled over. Its name and Latin name appears Roadrunner (dig-outtis tid-bittius). The bird beeps and zooms away starting the chase. Wile E. takes a straight-line shortcut instead of the road to catch up. Before Wile E. can come close, however, the Road Runner sets the road on fire with his blinding speed, causing Wile E. to burn his feet. He stomps out the fire on his paws, but finds his tail is also burning. Wile E., thinking fast, witches for water to cool his tail off. The Coyote rages at the camera, but nothing can be done except plan the next scheme.
1. Wile E. uses his frequent idea: swing from a high place armed with a javelin, looking to spear the Road Runner. This time, he simply plows into the ground as the Road Runner calmly passes on the right.
2. The Coyote stuffs a gun on a spring into a ground compartment and locks it with a safety lock, hoping to shoot his enemy, but due to the excessive spring force, the gun does a 180 and ends up on the opposite side of the Coyote, pointed in his face upside down. Wile E. plugs the barrel with his finger but still gets blasted in the face. The gun retracts back to the hole in the ground, pulling its owner with it.
3. Wile E. attaches himself to a tree catapult to throw himself towards a passing Road Runner, but instead he bounces himself on the ground and suffers repeating back and forth faceplants as the tree continually stretches to either side.
4. To block the Road Runner, the Coyote attaches a bunch of maces to a string and pole, and unwinds the string when he hears the bird approaching. It's an effective obstacle, and would have stopped the Road Runner except that the pole lifts itself out of the ground and drops on the hiding Coyote before the Road Runner passes. Wile E. is battered and tied up by the end of the fracas.
5. This time, the Coyote uses deception. He posts a detour and bridges a crevasse with a ladder that he has sabotaged with a cut in the structure, which will make it collapse if passed over. He hears the Road Runner, but doesn't see him, and he looks up to see the Road Runner safely perched on top of a high cliff, watching his every move. The angry Coyote uses his own broken ladder to climb up to the top, with predictably disastrous results. Wile E. falls into the canyon, grabs onto the second section of the ladder to alleviate the fall, and continues into the ground through each rung on the way down.
6. Now, Wile E. loads a circle of explosives into the center of a tire. He rolls the tire down a hill to meet the Road Runner, but the explosives stay behind and blow up their user.
7. The Coyote is loaded into a massive missile to chase the Road Runner, but when he sets it off, instead of launching the missile, he only launches himself out of it and through a rock face. He emerges from the resulting hole, blackened.
8. The final gag in this cartoon involves a pack of rocks from on high, ready to fall on the Road Runner when the trap door opens. But when Wile E. opens the trap door, the rocks remain intact because they're too densely packed. To try and fix this, the Coyote first runs to the top and stomps on them; no dice. Next, he procures a long, thin stick and uses it like an ice pick to force them out while standing under them. Pebbles start to fall, followed by stones then rocks. Wile E. finally comes to his senses and raises a sign: "IN HEAVEN'S NAME - WHAT AM I DOING?" (Also used in the Next Road Runner Cartoon) Too late; Wile E. drops the long thin stick and raises a tiny parasol to prepare for the resulting impact of huge rocks, and after the impact, a long lump forms on the Coyote's head with a white flag making the lump look like a flagpole. The flag reads "THE END" while it waves in the wind, accompanied by the song: "Taps".