The original cast returned to voice their characters and features the guest voice of Seth MacFarlane as "I.S.R.A.E.L." (Intelligent Smart Robot Animation Eraser Lady), and Vernon Wells as the villainous Network Head. While the television series was produced by Rough Draft Studios using digital ink and paint, the film was instead produced by Six Point Harness and done entirely in flash animation using Toon Boom and Adobe Flash Professional.
In Bedrock, a drunken and pregnant Toot is informed that someone has come to see her. The visitor turns out to be her old housemate Foxxy Love, who tries to tell her that their lives are in danger. This then flashes back to six months prior. Foxxy discovers that she can swear without being censored. When she discovers the show's control room, she realizes that the TV show Drawn Together has been cancelled. The housemates check their TV listings and find out that their time slot had been taken over by a TV show called "The Suck My Taint Show". Foxxy calls the network to find out why they were cancelled. The Network Head, upon hearing from Foxxy, learns that the housemates are still alive and summons I.S.R.A.E.L. (Intelligent Smart Robot Animation Eraser Lady), a robot designed specifically to erase cartoon characters. The Jew Producer warns the housemates before I.S.R.A.E.L. shows up, but he manages to escape just in time inside Foxxy's van.
Once they escape from I.S.R.A.E.L., Foxxy insists that the way for them to survive is to get their TV show back on the air, and suggests that they can seek out the Suck My Taint Girl for help. Clara, refusing to believe that she is not a real princess, wants to return to her kingdom, claiming that her father can protect them. Captain Hero, Xandir, and Ling-Ling decide to go with Clara, while Spanky and Wooldoor decide to go with Foxxy to try to get their show back on the air. While the others are arguing, Toot steals the van and drives off alone.
Back at the network, the Jew Producer tells the Network Head that he cannot bring himself to have the housemates erased, having become attached to them. The Network Head then tells him he wants the housemates dead because, one day, as his wife was driving his daughter to school, they passed a billboard advertising Drawn Together that featured Foxxy and Clara's hot tub kiss (from the episode Hot Tub). This terrifies the daughter, thinking that Foxxy is eating Clara's face. As the mother tries to calm down the daughter, they drive off a cliff into a vat of alligators (in a vat of sulfuric acid), killing them. The Jew Producer states that, despite this revelation, he will not help the Network Head with his mission, but the Network Head reveals that he has kidnapped the Jew Producer's son as a threat. The Jew Producer reluctantly agrees to help, and he and I.S.R.A.E.L. take off in pursuit of the housemates once again. Clara, Hero, Molly (a corpse Hero believes to be his girlfriend), Xandir, and Ling-Ling arrive at Clara's kingdom, expecting to find refuge. However, nobody there seems to recognize Clara. She encounters the king of the land, who is not her father, and even more shockingly, she sees a woman who appears to be the "real" princess. The guards end up dismembering and eventually killing Clara, but the other three manage to escape.
Meanwhile, Foxxy, Spanky, and Wooldoor visit the set of The Suck My Taint Show and meet the Suck My Taint Girl, who reveals herself to be a fan of the housemates' show. She tells the group that they were cancelled because vulgar and offensive content is only acceptable when your show "makes a point", and that if they want to get Drawn Together back on the air, they will need to get a point, which they can do by making a visit to Make-A-Point Land. She tells Foxxy that if she will bring the rest of the Drawn Together gang to meet her, she will take them to Make-A-Point Land. After tracking down the others, the remaining group return to the set of The Suck My Taint Show. The Suck My Taint Girl agrees to take the rest of the group to Make-A-Point Land so they can get a point.
The wizard of Make-A-Point Land agrees to give the group a point, and presents them with a box containing said point. Spanky protests by claiming that they should not open the box; that he is happier being disgusting for no reason. Some others agree with Spanky. Wooldoor disagrees, determined to get back on the air. He opens the box to find out it contains an eraser bomb which erases him from existence. The wizard explains he was forced to give them the box with an eraser bomb. It is then that the Network Head, the Jew Producer, and I.S.R.A.E.L. show up to erase the remaining cast. Foxxy asks how they knew they were going to the palace, and the Suck My Taint Girl reveals that she blackmailed them and is the Network Head's wife.
I.S.R.A.E.L. prepares to kill the housemates, but the Jew Producer manages to convince I.S.R.A.E.L. that they have a right to exist as she does. She then impales the Network Head on a spike. The Network Head then opens his coat to reveal that he had enough explosive erasers strapped to his waist to destroy all of Make-A-Point Land. As the Network Head drops the remote to explode Make-A-Point Land, the Suck My Taint Girl tries to grab it, but the Jew Producer dives on top of her to stop her. The housemates then make a getaway. The Jew Producer and the Suck My Taint Girl struggle for possession of the detonator, in the process dropping it, erasing all of Make-A-Point Land, including themselves. The housemates make it out just in time with the help of The Giant Who Shits Into His Own Mouth, an aptly-named guard of the palace that saved the housemates after using Clara's arms to prevent him from defecating into his mouth earlier.
The housemates visit the remains of the erased Drawn Together house. The Jew Producer's son shows up to inform them that he might be able to help them by giving them a direct-to-DVD movie. I.S.R.A.E.L. arrives at the scene and she and the giant become smitten with each other. Everyone happily laughs until Spanky accidentally steps on an eraser bomb caught in the ground, erasing them all from existence.Jess Harnell as:Captain Hero, a chauvinistic, perverted, necrophiliac, repressed bisexual, and lecherous parody of Superman and other superheroes, with a visual style taken from the cartoons of Bruce Timm and Max FleischerWile E. CoyoteRhino Guard 1 (Brian)The KingBedrock bartenderCree Summer as:Foxxy Love, a sharp-tongued ghetto-parody of Valerie Brown from Hanna-Barbera's Josie and the PussycatsSuck My Taint Girl, the star of The Suck My Taint Show, a spoof of South ParkThe Network Head's wifeOld LadyJames Arnold Taylor as:Wooldoor Sockbat, a bizarre children's show character in the mold of SpongeBob SquarePants or Stimpy who displays many of the typical reality-defying behaviors of Looney Tunes charactersThe Jew Producer, the person in charge of the Drawn Together show, who grew attached to the characters and defended them from I.S.R.A.E.L.Barney RubbleEddie, the Jew Producer's Christian next-door neighborBrainy and Hefty SmurfThe Make-A-Point wizard"Suck My Taint Show" audience membersAdam Carolla as Spanky Ham, a sex-obsessed, toilet-humored, obnoxious pig and a parody of Internet Flash cartoon characters.Tara Strong as:Princess Clara, a pampered, hyper-religious, and bigoted princess who is a parody of Disney princesses like Ariel from The Little Mermaid (1989) and Belle from Beauty and the Beast (1991)Toot Braunstein, an overweight alcoholic sex symbol from the 1920s reminiscent of Betty BoopSasha, the Network Head's daughterThe red-haired princessBetty RubbleBedrock BlondeAbbey DiGregorio as Ling-Ling, a homicidal anime character based on Pikachu from the Pokémon franchise, who battles using various supernatural powers/abilities (reminiscent of anime) and speaks in pseudo-Japanese gibberish (or "Japorean", as DiGregorio calls it) with English subtitles.Jack Plotnick as Xandir P. Wifflebottom, a hypersensitive, homosexual, overemotional, and effeminate parody of video-game heroes like Link from The Legend of Zelda series.Seth MacFarlane as I.S.R.A.E.L. (Intelligent Smart Robot Animation Eraser Lady), a robot deployed by the Network Head to permanently erase the entire Drawn Together gang.Vernon Wells as The Network Head, the evil head of the television network who cancelled Drawn Together and attempts to erase them by various means.Dave Jeser (uncredited) as The Giant Who Shits Into His Own Mouth / Rhino Guard 2Matt Silverstein (uncredited) as the Jew Producer's sonKaitlyn Robrock (uncredited) as Smurfette
Though originally announced for a November 2009 release, the film's release date was pushed to March 23, 2010, then released on April 20, 2010. The film premiered at the 2010 SXSW festival in Austin, Texas, on March 18, 2010. The film was released April 20, 2010 on DVD, and on Blu-ray exclusively at Best Buy. The film was released on DVD in Australia later that year on October 6, 2010.
Common Sense Media, a site that reviews the content of movies for parents, panned the movie and gave it one star, criticizing its vulgarity, stating that the film is "filled to the brim with lewd sexual acts, language, and violence. The cartoon parody is meant to push the boundries of taste, but amidst violence against women, the violation of corpses, kids asking to be sexually abused, heads blown off at close range, the drinking of baby blood ... who -- and especially what child -- is going to be thinking of this as a parody?"
IGN also gave the movie a critical review, writing that a "great comedic opportunity was wasted on cheap one-dimensional gags and boring sex jokes."
In contrast DVD Verdict was more favorable, commenting that the movie was "first and foremost a goodbye gift to fans of the series and they should have no problem enjoying the myriad references and in-jokes scattered about, as well as all of the crude humor."
The film was criticised for its antisemitism, even though the producers said that "it was supposed to make fun of bigotry".