Synonyms THDOC PubChem CID 91475 3D model (Jmol) Interactive image Molar mass 334.4929 g/mol | CAS Number 567-03-3 ECHA InfoCard 100.008.457 Formula C21H34O3 Pubchem 91475 | |
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Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid. It is synthesized from the adrenal hormone deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid dehydrogenase. THDOC is a potent positive allosteric modulator of the GABAA receptor, and has sedative, anxiolytic and anticonvulsant effects. Changes in the normal levels of this steroid particularly during pregnancy and menstruation may be involved in some types of epilepsy (catamenial epilepsy) and premenstrual syndrome, as well as stress, anxiety and depression.
References
Tetrahydrodeoxycorticosterone Wikipedia(Text) CC BY-SA