Type Whole antibody Target NGF Synonyms RN624 | Source Humanized (from mouse) ATC code none CAS Number 880266-57-9 | |
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What does tanezumab mean
Tanezumab (INN, codenamed RN624) is a monoclonal antibody against nerve growth factor. It was developed by Pfizer as a treatment for pain.
Contents
- What does tanezumab mean
- News update pfizer suspends trials of pain drug tanezumab at fda request
- References
In 2009 there was a Phase III trial for knee pain due to osteoarthritis (OA). Another Phase III trial for hip pain in OA was halted in June 2010 when some patients needed hip replacement.
Tanezumab is undergoing Phase II clinical trials for the treatment of various pain entities, including chronic low back pain, bone cancer pain, and interstitial cystitis.
In March of 2012, the Anti-NGF Testing - FDA Committee voted in favor of a continuation of the development of nerve-blocking medications, as long as certain safety precautions were observed.
A Phase III trial published in 2013 found tanezumab was superior to placebo for painful hip osteoarthritis.