Suvarna Garge (Editor)

Tachykinin receptor 2

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Species
  
Human

Entrez
  
6865

Human
  
Mouse

Ensembl
  
ENSG00000075073

Tachykinin receptor 2

Aliases
  
TACR2, NK2R, NKNAR, SKR, TAC2R, Tachykinin receptor 2

External IDs
  
MGI: 98477 HomoloGene: 55548 GeneCards: TACR2

Substance-K receptor is a protein that in humans is encoded by the TACR2 gene.

Contents

Function

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A.

Selective Ligands

Several selective ligands for NK2 are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as an anxiolytic and antidepressant.

Agonists

  • GR-64349 - potent and selective agonist, EC50 3.7nM, 7-amino acid polypeptide chain. CAS# 137593-52-3

    • Antagonists

  • Ibodutant
  • Saredutant
  • GR-159,897
  • MEN-10376 - potent and selective antagonist, 7-amino acid polypeptide chain. CAS# 135306-85-3

    • References

    Tachykinin receptor 2 Wikipedia
    (Text) CC BY-SA


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