Species Human Entrez 51567 | Human Mouse Ensembl ENSG00000111802 | |
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Aliases TDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 2 External IDs MGI: 1860486 HomoloGene: 9591 GeneCards: TDP2 | ||
TRAF and TNF receptor-associated protein is a protein that in humans is encoded by the TTRAP gene.
Contents
Function
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
Interactions
TTRAP has been shown to interact with ETS1, TNFRSF1B and CD40.
References
TTRAP Wikipedia(Text) CC BY-SA