Species Human Entrez 10077 | Human Mouse Ensembl ENSG00000064201 | |
 | ||
Aliases TSPAN32, ART1, PHEMX, PHMX, TSSC6, tetraspanin 32 External IDs MGI: 1350360 HomoloGene: 10650 GeneCards: TSPAN32 | ||
Tetraspanin-32 is a protein that in humans is encoded by the TSPAN32 gene.
Contents
Function
This gene is described as a member of the tetraspanin superfamily whose expression is confined to hematopoietic tissues.
Clinical significance
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function.