Species Human Entrez 4308 | Human Mouse Ensembl n/a | |
 | ||
Aliases TRPM1, CSNB1C, LTRPC1, MLSN1, transient receptor potential cation channel subfamily M member 1 External IDs OMIM: 603576 MGI: 1330305 HomoloGene: 19940 GeneCards: TRPM1 | ||
Transient receptor potential cation channel subfamily M member 1 is a protein that in humans is encoded by the TRPM1 gene.
Contents
Function
The protein encoded by this gene is a member of the transient receptor potential (TRP) family of non-selective cation channels. The expression of this protein is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis. The expression of the TRPM1 gene is regulated by the Microphthalmia-associated transcription factor.
Clinical significance
Mutations in TRPM1 are associated with congenital stationary night blindness in humans and coat spotting patterns in Appaloosa horses.
References
TRPM1 Wikipedia(Text) CC BY-SA