Species Human Entrez 26133 | Human Mouse Ensembl ENSG00000100991 | |
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Aliases TRPC4AP, C20orf188, PPP1R158, TRRP4AP, TRUSS, transient receptor potential cation channel subfamily C member 4 associated protein External IDs OMIM: 608430 MGI: 1930751 HomoloGene: 9224 GeneCards: TRPC4AP | ||
Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.
Contents
Model organisms
Model organisms have been used in the study of TRPC4AP function. A conditional knockout mouse line, called Trpc4aptm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on mutant mice and three significant abnormalities were observed. Few homozygous mutant embryos were identified during gestation, and thus fewer than expected survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; females had an abnormal anagen phase of the hair cycle.
Interactions
TRPC4AP has been shown to interact with TNFRSF1A.