TRNA (guanine10 N2) methyltransferase

Updated on Dec 01, 2023

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EC number 2.1.1.214 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

TRNA (guanine¹⁰-N²)-methyltransferase (EC 2.1.1.214, (m2G10) methyltransferase, Trm11-Trm112 complex) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine¹⁰-N²)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine¹⁰ in tRNA ⇌ S-adenosyl-L-homocysteine + N²-methylguanine¹⁰ in tRNA

tRNA (guanine¹⁰-N²)-methyltransferase from yeast does not catalyse the methylation from N²-methylguanine¹⁰ to N²-dimethylguanine¹⁰ in tRNA.

References

TRNA (guanine10-N2)-methyltransferase Wikipedia

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