Entrez 84676 | Ensembl ENSG00000158022 | |
![]() | ||
Aliases TRIM63, IRF, MURF1, MURF2, RNF28, SMRZ, tripartite motif containing 63 External IDs MGI: 2447992 HomoloGene: 41878 GeneCards: TRIM63 |
E3 ubiquitin-protein ligase TRIM63 is an enzyme that in humans is encoded by the TRIM63 gene.
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.
References
TRIM63 Wikipedia(Text) CC BY-SA