Species Human Entrez 4591 | Human Mouse Ensembl ENSG00000108395 | |
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Aliases TRIM37, MUL, POB1, TEF3, tripartite motif containing 37 External IDs MGI: 2153072 HomoloGene: 9084 GeneCards: TRIM37 | ||
Tripartite motif-containing protein 37 is a protein that in humans is encoded by the TRIM37 gene.
Contents
Function
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein–protein and/or protein–nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.
Interactions
TRIM37 has been shown to interact with PRC1.