Trisha Shetty (Editor)

TRIM3

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Species
  
Entrez
  
10612

Human
  
Ensembl
  
ENSG00000110171

TRIM3

Aliases
  
TRIM3, BERP, HAC1, RNF22, RNF97, tripartite motif containing 3

External IDs
  
MGI: 1860040 HomoloGene: 21290 GeneCards: TRIM3

Tripartite motif-containing protein 3 is a protein that in humans is encoded by the TRIM3 gene.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.

Interactions

TRIM3 has been shown to interact with Actinin alpha 4.

References

TRIM3 Wikipedia


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