Species Human Entrez 373 | Human Mouse Ensembl ENSG00000113595 | |
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Aliases TRIM23, ARD1, ARFD1, RNF46, tripartite motif containing 23 External IDs MGI: 1933161 HomoloGene: 1251 GeneCards: TRIM23 | ||
GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.
Contents
Function
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phospholipase D activation. Three alternatively spliced transcript variants for this gene have been described.
Interactions
TRIM23 has been shown to interact with TRIM31, TRIM29 and PSCD1.