Species Human Entrez 54210 | Human Mouse Ensembl ENSG00000124731 | |
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Aliases TREM1, CD354, TREM-1, triggering receptor expressed on myeloid cells 1 External IDs MGI: 1930005 HomoloGene: 10243 GeneCards: TREM1 | ||
Gene music using protein sequence of trem1 triggering receptor expressed on myeloid cells 1
Triggering receptor expressed on myeloid cells 1 is a protein that in humans is encoded by the TREM1 gene.
Contents
- Gene music using protein sequence of trem1 triggering receptor expressed on myeloid cells 1
- Function
- Model organisms
- References
Function
Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936).[supplied by OMIM]
Model organisms
Model organisms have been used in the study of TREM1 function. A conditional knockout mouse line called Trem1tm1(KOMP)Vlcg was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping
