Species Human Entrez 80342 | Human Mouse Ensembl ENSG00000009790 | |
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Aliases TRAF3IP3, T3JAM, TRAF3 interacting protein 3 External IDs MGI: 2441706 HomoloGene: 11885 GeneCards: TRAF3IP3 | ||
TRAF3-interacting JNK-activating modulator is a protein that in humans is encoded by the TRAF3IP3 gene.
Contents
Model organisms
Model organisms have been used in the study of TRAF3IP3 function. A conditional knockout mouse line, called Traf3ip3tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program—a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on homozygous mutant mice and two significant abnormalities were observed. Males had a decrease in white blood cell count and females had an increased susceptibility to bacterial infection.
Interactions
TRAF3IP3 has been shown to interact with STRN, MOBKL3, STK24 and FAM40A.