Species Human Entrez 8717 | Human Mouse Ensembl ENSG00000102871 | |
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Aliases TRADD, Hs.89862, TNFRSF1A associated via death domain External IDs OMIM: 603500 MGI: 109200 HomoloGene: 2807 GeneCards: TRADD | ||
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.
Contents
TRADD is an adaptor protein.
Function
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.
Interactions
TRADD has been shown to interact with:
References
TRADD Wikipedia(Text) CC BY-SA