Species Human Entrez 7164 | Human Mouse Ensembl ENSG00000111907 | |
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Aliases TPD52L1, D53, hD53, tumor protein D52-like 1 External IDs MGI: 1298386 HomoloGene: 2468 GeneCards: TPD52L1 | ||
Tumor protein D53 is a protein that in humans is encoded by the TPD52L1 gene.
Contents
Function
This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.
Interactions
TPD52L1 has been shown to interact with TPD52L2 and TPD52.
References
TPD52L1 Wikipedia(Text) CC BY-SA