Species Human Entrez 54472 | Human Mouse Ensembl ENSG00000078902 | |
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Aliases TOLLIP, IL-1RAcPIP, toll interacting protein External IDs MGI: 1891808 HomoloGene: 10375 GeneCards: TOLLIP | ||
Toll interacting protein, also known as TOLLIP, is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene.
Contents
Function
It is an inhibitory adaptor protein within Toll-like receptors (TLR). The TLR pathway is a part of the innate immune system that recognizes structurally conserved molecular patterns of microbial pathogens, leading to an inflammatory immune response.
Clinical significance
Polymorphisms in TLR genes have been implicated in various diseases like atopic dermatitis. Recently, variations in the TOLLIP gene have been associated with tuberculosis and idiopathic pulmonary fibrosis.
Interactions
TOLLIP has been shown to interact with TOM1, TLR 2, TLR 4 and IL1RAP.
References
TOLLIP Wikipedia(Text) CC BY-SA