Species Human Entrez 10972 | Human Mouse Ensembl ENSG00000170348 | |
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Aliases TMED10, P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1, transmembrane p24 trafficking protein 10 External IDs MGI: 3782198 HomoloGene: 4972 GeneCards: TMED10 | ||
Transmembrane emp24 domain-containing protein 10 is a protein that in humans is encoded by the TMED10 gene.
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
References
TMED10 Wikipedia(Text) CC BY-SA