Species Human Entrez 7101 | Human Mouse Ensembl ENSG00000112333 | |
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Aliases NR2E1, TLL, TLX, XTLL, nuclear receptor subfamily 2 group E member 1 External IDs OMIM: 603849 MGI: 1100526 HomoloGene: 37750 GeneCards: NR2E1 | ||
Nuclear receptor TLX (homologue of the Drosophila tailless gene) also known as NR2E1 (Nuclear receptor subfamily 2 group E member 1) is a protein that in humans is encoded by the NR2E1 gene. TLX is a member of the nuclear receptor family of intracellular transcription factors.
Function
TLX regulates the expression of another nuclear receptor, RAR.
TLX also is essential for normal brain-eye coordination and appears to play a role in control of aggressive behavior.
Adult neural stem cells are nuclear receptor TLX-positive and TLX expression in these cells is crucial in maintaining their undifferentiated state. Furthermore, TLX regulates adult neural stem cell proliferation. Removal of TLX from the adult mouse brain resulted in a reduction of stem cell proliferation and spatial learning.
Tlx-positive cells of the subventricular zone of adult mouse brain are self-renewing stem cells. Mutation of the Tlx gene in adult mouse brain leads to complete loss of neurogenesis in the subventricular zone. Tlx is also required for transition from radial glial cells to astrocyte-like neural stem cells.