Entrez 7021 | Ensembl ENSG00000008196 | |
Aliases TFAP2B, AP-2B, AP2-B, transcription factor AP-2 beta External IDs MGI: 104672 HomoloGene: 20688 GeneCards: TFAP2B | ||
Gene music using protein sequence of tfap2b transcription factor ap 2 beta activating enhancer bi
Transcription factor AP-2 beta also known as AP2-beta is a protein that in humans is encoded by the TFAP2B gene.
Contents
- Gene music using protein sequence of tfap2b transcription factor ap 2 beta activating enhancer bi
- Function
- Clinical significance
- References
Function
AP-2 beta is a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor.
Clinical significance
Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.