CAS Number 372523-75-6 IUPHAR/BPS 4038 3D model (Jmol) Interactive image Pubchem 10408514 | PubChem CID 10408514 Formula C23H31N3O3 Molar mass 397.509 g/mol IUPHAR/BP 4038 | |
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TCS-OX2-29 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX2, with an IC50 of 40nM and selectivity of around 250x for OX2 over OX1 receptors. Orexin antagonists are expected to be useful for the treatment of insomnia, with subtype-selective antagonists such as TCS-OX2-29 potentially offering more specificity of action compared to non-selective orexin antagonists like almorexant.
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TCS-OX2-29 Wikipedia(Text) CC BY-SA