Orexin antagonist

Updated on Nov 01, 2023

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An orexin receptor antagonist is a drug that inhibits the effect of orexin by acting as a receptor antagonist of the orexin receptor. Potential applications include treatment of sleep disorders such as insomnia.

Examples

Almorexant, development of the drug was abandoned in January 2011

Lemborexant

SB-334,867, has been shown to produce sedative and anorectic effects in animals,

SB-408,124

SB-649,868, in development for potential use in sleep disorders

Suvorexant, approved for use in sleep disorders under the brand name Belsomra

TCS-OX2-29, OX₂ selective

RTIOX-276, OX₁ selective

References

Orexin antagonist Wikipedia

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