Species Human Entrez 6923 | Human Mouse Ensembl ENSG00000103363 | |
 | ||
Aliases ELOB, SIII, TCEB2, transcription elongation factor B subunit 2 External IDs HomoloGene: 134544 GeneCards: ELOB | ||
Transcription elongation factor B polypeptide 2 is a protein that in humans is encoded by the TCEB2 gene.
Contents
Function
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Interactions
TCEB2 has been shown to interact with: